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Job Description
Please note this job requires business level Japanese in speaking, writing, and reading.
OBJECTIVES/PURPOSE:
Leads planning and implementation of in vitro studies to identify and characterize hit/lead molecules for SAR and subsequent in vivo pharmacology studies.
Serves as an IVP scientific lead in Japan to establish sustainable in vitro platform and its operational framework in the lab closely working with relevant functions/divisions.
Works as a global IVP leadership team member to improve probability of success of small molecule asset generation by developing and implementing efficient in vitro screening cascade.
Responsible for the generation of novel in vitro assays to support small molecule projects across therapeutic areas.
Responsible for quality of in vitro pharmacology data and assay performance.
Manages in vitro assay data pertaining to synthetic compounds and small molecule libraries
Works with external vendors to manage any in vitro pharmacology screening work conducted at CROs
ACCOUNTABILITIES:
Identifies bottlenecks of small molecule programs, and develops strategic plans and methodology for in vitro studies to address key challenges
Participates in program teams as a representative of IVP and lead scientific discussion on screening methods and cascade
Develops in vitro assays and executes planned studies internally and/or externally (lead optimization support, screening for new chemotype generation, mechanistic analysis on molecular biology, primary/secondary/counter/confirmatory assay development and implementation, etc)
Organizes and manages committees for in vitro assay data management pertaining to synthetic compounds and small molecule libraries to effectively leverage internal databases achieving global harmonization
Evaluates necessity of capital investment for in vitro platform in Takeda Shonan site
Evaluates CROs for relevant services and promote their effective use
Develops talents so that internal IVP function can sustainably grow keeping up with cutting edge new technologies
CORE ELEMENTS RELATED TO THIS ROLE:
Provides program team with deep scientific insights from molecular biology perspective
Develops internal capability striking balance between insourcing and outsourcing
Pursues efficiency proactively introducing automation technologies
DIMENSIONS AND ASPECTS:
Technical/Functional (Line) Expertise
Being up to date on latest pharmacology assays and data analysis
Has knowledge to utilize compound and assay databases
Miniaturization of assays in order to increase assay bandwidth
Demonstrates broad technical program knowledge
Acts as the recognized scientific resource on an aspect of a program
Demonstrates effective project management skills
Leadership Exerts strong leadership to elevate internal scientific level of molecular biology globally
Posesses tenacious mind to achieve critical goals of the organization
Plays a pivotal role in establishing one global IVP team in close collaboration with members in other sites
Decision-making and Autonomy
Plays a pivotal role in IVP lab operation in Takeda Shonan site
Judgement of ideal balance of internal and external resource allocation for in vitro studies
Interaction
Interacts with broad range of stakeholders internally (e.g. Drug Discovery Unit, DMPK, Safety) and externally (CROs)
Frequently communicates with members based in Boston site
Innovation
Maintains open mindset to adopt new innovative technologies/frameworks to achieve best practice
Not stick to historical standard
Strives to identify/generate differentiated molecules from molecular biology standpoint
Complexity
Needs to work with diverse people from technicians to area-specific experts in interdisciplinary projects
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:
PhD degree in a scientific discipline with 5+ years experience , or
MS with 7+ years experience, or
BS with 9+ years experience in in vitro assay development and/or molecular biology
Familiarized with both cell-based and cell-free assays including biochemical assays (e.g. binding and enzymatic assays) to evaluate small molecules
Preferably, with experience and knowledge for biophysical assays
Posses sufficient knowlege on assay material preparation such as procedures of cloning, genetic modifications of cell lines, protein expression and purification, etc.
Experiece and/or familiarity with molecular screening
Broad familiarity with overall process of preclinical research
Good command of Excel based data analysis
Good communication skill to establish good relationship with global members
Takeda Compensation and Benefits Summary:
Allowances: Commutation, Housing, Overtime Work etc.
Salary Increase: Annually, Bonus Payment: Twice a year
Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45
Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.
Flexible Work Styles: Flextime, Telework
Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.
Important Notice concerning working conditions:
It is possible the job scope may change at the company’s discretion.
It is possible the department and workplace may change at the company’s discretion.
